Pyruvate kinase catalyzes the most energetically rich reaction of glycolysis. You might wonder why pyruvate kinase, the last enzyme in the pathway, is regulated. This molecule has an inhibitory effect on the corresponding gluconeogenesis enzyme, fructose-1,6-bisphosphatase (F1,6BPase). It is activated by several molecules, most importantly fructose-2,6- bisphosphate (F2,6BP). Reciprocal regulation is important when anabolic and corresponding catabolic pathways are occurring in the same cellular location.Īs an example, consider regulation of PFK. Reciprocal regulation occurs when the same molecule or treatment (phosphorylation, for example) has opposite effects on catabolic and anabolic pathways.
Glycolysis is regulated in a reciprocal fashion compared to its corresponding anabolic pathway, gluconeogenesis.
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